Research Group
纳米靶向治疗研究组
日期:2018-03-07研究组长
段友容博士，研究员，博士生导师
研究方向
①逆转或降低肿瘤耐药性药物递送系统设计及应用；
②肿瘤靶向药物（基因）载体设计以及抗肿瘤给药系统的构建（缓控释）；
③载药超声造影剂用于可视化治疗；
④温敏复合凝胶给药系统对肿瘤的治疗；
⑤生物标志物检测。
团队成员
孙颖 博士 硕士生导师 ysun@shsci.org
张佳利 博士 jlzhang@shsci.org
张伟 博士 wzhang@shsci.org
武志华 博士 zhwu@shsci.org
余坚 本科 yujian@shsci.org
田宇 博士 ytian@shsci.org
代表性论文
1. Wang Liting, Shen Qin, Liao Hongzhe, Fu Hao, Wang Qi, Yu Jian, Chen Chuanrong, Dong Yang, Yang Xupeng, Guo Qianqian, Zhang Jiali, Zhang Jian, Zhang Wei, Lin Houwen, Duan Yourong, Multi-Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation, Advanced Science 2021, 2003558, DOI:10.1002/advs.202003558.
2. Wang Qi, He Yang, Shen Ming, Huang Lili, Ding Li, Hu Jian, Dong Yang, Fu Hao, Wang Quan, Sun Ying, Zhang Lin, Cao Jun, Duan Yourong, Precision Embolism Biocompatible TemperatureSensitive Hydrogels as Novel Embolic Materials for Both Mainstream and Peripheral Vessels, Advanced Functional Materials, 2021, 31(8): 2011170.
3. Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan, Ying Sun. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478.
4. De Zhao, Zhihua Wu, Jian Yu, Hongzhi Wang, Yaogang Li, Yourong Duan. Highly sensitive microfluidic detection of carcinoembryonic antigen via a synergetic fluorescence enhancement strategy based on the micro/nanostructure optimization of ZnO nanorod arrays and in situ ZIF-8 coating. Chemical Engineering Journal. 2020, 383: 123230.
5. Jiali Zhang, Chuanrong Chen, Hao Fu, Jian Yu, Ying Sun, Hui Huang, Yuanjia Tang, Nan Shen, Yourong Duan. MicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector/Regulatory T Cells Balance. ACS Nano, 2020, 14, 4414-4429.
7. Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan, Ying Sun. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065.
8. Hao Fu, Chongchong Miao, Yuanpeng Rui, Fenglin Hu , Ming Shen , Hong Xu , Chunfu Zhang , Yi Dong, Wenping Wang, Hongchen Gu, Yourong Duan. Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron oxide nanoparticles and its mechanism investigation. Biomaterials. 2019, 222: 119442.
9. Dong Yang, Liao Hongze, Fu Hao, Yu Jian, Guo Qian, Wang Qi, Duan Yourong. pH-Sensitive Shell-Core Platform Block DNA Repair Pathway To Amplify Irreversible DNA Damage of Triple Negative Breast Cancer. ACS Appl Mater Interfaces. 2019, 42: 38417-38428.
10. Qi Wang, Xiangyu Zhang, Hongze Liao, Ying Sun, Li Ding, Yanwei Teng, Wei-Hong Zhu, Zhirong Zhang, Yourong Duan. Multifunctional Shell–Core Nanoparticles for Treatment of Multidrug Resistance Hepatocellular Carcinoma. Advanced Functional Materials. 2018, 201706124.
11. Ying Sun, Qi Wang, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics, 2017, 7(18): 4424-4444.
12. Li Ding, Qi Wang, Ming Shen, Ying Sun, Xiangyu Zhang, Can Huang, Jianhua Chen, Rongxin Li, Yourong Duan. Thermoresponsive Nanocomposite Gel for Local Drug Delivery to Suppress the Growth of Glioma by Inducing Autophagy. Autophagy. 2017, 13(7): 1176-1190.
13. Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun, Xinyuan Liu, Yourong Duan. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560.
14. Can Huang, Ying Sun, Ming Shen, Xiangyu Zhang, Pei Gao, Yourong Duan. Altered Cell Cycle Arrest by Multifunctional Drug Loaded Enzymatically-Triggered Nanoparticles. ACS Applied Materials & Interfaces. 2016, 8: 1360−1370.
15. Wang Qi, Sun Ying, Zhang Zhirong, Duan Yourong. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. 2015, 56: 229-240.
16. Shen Ming, Xu Yuanyuan, Sun Ying, Han Baoshan, Duan Yourong. Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy. ACS Applied Materials & Interfaces. 2015, 7: 20530-20537.
17. Qi Wang, Peifeng Liu, Ying Sun, Tao gong, Xun Sun, Mingjie Zhu, Zhirong zhang, Yourong Duan. Preparation and properties of biocompatible PS-PEG/calcium phosphate nanospheres. Nanotoxicology, 2015, 9(2): 190-200.
18. Zelai He, Ying Sun, Qi Wang, Ming Shen, Mingjie Zhu, Fengqian Li, Yourong Duan. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL-Copolymer-Prepared Nanoparticles. Journal of Physical Chemistry C. 2015, 119(6): 3348-3362.
科研项目：
1. 国家自然科学基金面上项目，81972886，PRSS22介导的递送系统实现多靶定向敲除克服非小细胞肺癌耐药与转移的研究
2. 国家自然科学基金面上项目，81773272，共载siRNA/PTX序贯释放“双管齐下”抗前列腺癌耐药研究
3. 国家自然科学基金面上项目，81771839，电荷反转型共载Pt(IV)/siRNA纳米超声-磁共振双模态造影剂用于可视化治疗卵巢癌耐药的研究
4. 国家自然科学基金面上项目，81572999，微环境响应胞内质子介导释放ZD55-IL-24纳米靶向递送系统抑制肝癌转移作用及机制研究
5. 国家自然科学基金面上项目，81472841，磷脂/磷酸钙壳核组装序贯给药克服脑胶质瘤细胞耐药研究
6. 国家自然科学基金面上项目，81272568，两相释药降低乳腺癌细胞耐药靶向给药系统的研究
7. 国家自然科学基金青年项目，81301973，多重靶向酶响应型载Au-Pt(IV)纳米载体的构建及对卵巢癌的治疗研究
8. 国家自然科学基金青年项目，81502692，胞内外阶梯式触发的钙磷复合脂质药物基因共递送系统对三阴性乳腺癌的治疗研究
获得专利
1. 磷酸钙和两亲性聚合物复合载药纳米微球、制备方法和用途. 中国，ZL200910198765.X
2. 聚乙二醇-聚乳酸羟基乙酸-聚赖氨酸纳米递送系统、制备方法及其应用. 中国，ZL200910247576.7
3. 用于治疗肿瘤的药物缓释血管栓塞凝胶剂及其制备方法. 中国，ZL201110088056.3
4. 注射用整合素配体修饰的载药肿瘤靶向阳离子聚合物. 中国，ZL200710039337.3
5. 双腔微导管. 中国，ZL201620276998.2
6. 核壳结核壳结构聚合物/纳合纳米合纳米米金复合纳米材料及其制备方法和应用. 中国，ZL201210246282.4
7. 一种预防和治疗前列腺炎穴位缓释贴片及其制品、制备方法和用途. 中国，ZL200710043634.5
8. 脂质体硫酸钙复合纳米人工骨、制备方法和应用. 中国，ZL200910048164.0
9. 仿生磷脂聚合物细胞膜及其制备方法和用途. 中国，ZL200710129554.1
10. 肿瘤细胞及肿瘤血管双靶向纳米粒、构建方法及应用. 中国，ZL 201510503842.3
11. 一种治疗胆系肿瘤的药物纳米复合温敏凝胶剂. 中国，ZL201610046742.7
12. 一种复合显影温敏凝胶栓塞剂、制备方法及其应用. 中国，ZL201610207908.9