课题组长

卜军教授，主任医师，博士生导师，教育部长江学者特聘教授，国家杰出青年基金获得者。

研究方向

肿瘤与代谢及炎症性疾病密切相关。聚焦代谢及炎症通路，为肿瘤与代谢及炎症性疾病治疗提供新的靶点及策略。

团队成员 

研究组成员：

卜军，博士，教授，研究组长，硕士生及博士生导师

姜萌，博士，副教授，硕士生导师

谢玉泉，博士，副教授，博士生导师

邵琴，博士，副教授，硕士生导师

陆熙园，博士，研究员，博士生导师

葛恒，博士，副主任医师，硕士生导师

丁嵩，博士，副主任医师，硕士生导师

袁安彩，博士，助理研究员

胡刘华，硕士，助理研究员

冯牡蜓，实验技术员

博士研究生：

徐龙伟，高灵辰，高宇（直博生），童仁洋（直博生），孙灵跃，施剑峰；上海交通大学医学院（附属仁济医院）；内科学专业

代表性论文

1.    Zhao Y, Gao L, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Wang F, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease. Hepatology. 2018;68(3):897-917.

2.    He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J*. The Nuclear Melatonin Receptor RORα Is a Novel Endogenous Defender Against Myocardial Ischemia/Reperfusion Injury. J Pineal Res. 2016;60(3):313-26.

3.    He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J*. Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy. Hypertension. 2016;67(6):1237-48.

4.    Jiang Y, Bai J, Tang L, Zhang P, Pu J*. Anti-CCL21 Antibody Attenuates Infarct Size and Improves Cardiac Remodeling After Myocardial Infarction. Cell Physiol Biochem.2015;37(3):979-90.

5.    He Q, Pu J*, Yuan A, Yao T, Ying X, Zhao Y, Xu L, Tong H, He B. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol, 2014;13(1): 149.

6.    Guo Q, Wu LM, Wang Z, Shen JY, Su X, Wang CQ, Gong XR, Yan QR, He Q, Zhang W, Xu JR*, Jiang M*, Pu J*. Early Detection of Silent Myocardial Impairment in Patients with New Onset Drug-Naïve Systemic Lupus Erythematosus - A Three-Center Prospective Study (Myocardial Impairment in New Onset SLE). Arthritis Rheumatol. 2018 Aug 2. doi: 10.1002/art.40671. [Epub ahead of print]

7.    Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, Ji Q, Tong R, Fu Y, Gao Y, Su Y, Yuan A, He B*, Pu J*. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018;45(3):125-35.

8.    Zhao Y, Xu L, Ding S, Lin N, Ji Q, Gao L, Su Y, He B*, Pu J*. Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy. J Pineal Res. 2017;62(3).

9.    Gao Y, Zhao Y, Yuan A, Xu L, Huang X, Su Y, Gao L, Ji Q, Pu J*, He B*. Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice. Exp Cell Res. 2018 Oct 15;371(2):301-10.

10.  Zhao YC, Xu LW, Ding S, Ji QQ, Lin N, He Q, Gao LC, Su YY, Pu J*, He B*. Nuclear receptor retinoid-related orphan receptor α deficiency exacerbates high-fat diet-induced cardiac dysfunction despite improving metabolic abnormality. Biochim Biophys Acta. 2017;1863(8):1991-2000.

11.  Sun B, Li X, Liu X*, Ge X, Lu Q, Zhao X, Pu J*, Xu J, Zhao H*. Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2017;16(1):111.

12.  Ji Q, Zhao Y, Yuan A, Pu J*, He B*. Deficiency of liver-X-receptor-α reduces glucose uptake and worsens post-myocardial infarction remodeling. Biochem Biophys Res Commun. 2017;488(3):489-95.

13.  Deng KQ, Wang A, Ji YX, Zhang XJ, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu XY, Zhao Y, Gao L, Yang Q, Zhu XH, Wei X, Pu J*, Li H*. Suppressor of IKKε is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016;7:11432.

14.  Ying X, Zhao Y, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J*, He B*. Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling. Hypertension. 2016;68(5):1160-70.

15.  Ge H, Yuan W, Liu J, He Q, Ding S, Pu J*, He B*. Functional relevance of protein glycosylation to the pro-inflammatory effects of extracellular matrix metalloproteinase inducer (EMMPRIN) on monocytes/macrophages. PLoS One. 2015;10(2):e0117463.

16.  Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J*, He B*. Vitamin d Receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal, 2015; 22(8): 633-50.

17.  He Q, Pu J*, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL*, He B*. Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury. Circ Heart Fail, 2014;7(6): 1032-41.

18.  Pu J, Ding S, Ge H, Han Y, Lin R, Guo J, Lin R, Su X, Zhang H, Chen L, He B. EARLY-MYO Investigators. (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation. 2017; 136(16):1462-73.

19.  Pu J, Mintz GS, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments. J Am Coll Cardiol. 2014; 63(21):2220-33.

20.  Pu J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau W, Ma XL, He B. Cardiomyocyte Expressed Farnesoid-X-Receptor is a Novel Apoptosis Mediator and Contributes to Myocardial Ischemia/Reperfusion Injury. Eur Heart J. 2013; 34:1834-45. 

21.  Pu J, Mintz GS, Brilakis ES, Banerjee S, Abdel-Karim AR, Maini B, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J.2012; 33:372-83.

在研项目

1. 科技部重点研发计划1项（2018YFC1312800），2018/09-2020/12、1534万元、在研、项目总负责人及首席科学家。

2. 上海市科委优秀学术带头人计划1项（18XD1402400），2018/05-2021/4、40万元、在研、主持。

3. 国家杰出青年基金1项（81625002），2017/01-2020/12、350万元、在研、主持。

4. 上海市申康临床创新行动计划项目1项（16CR3034A），2016/12-2019/06、50万元、在研、主持。