课题组长

姚明博士，研究员，博士生导师

研究方向

1．肿瘤动物模型的建立、高转移动物模型及细胞系的筛选；

2．肺癌发生发展和侵袭转移的分子机制。

团队成员

闫明霞，博士，副研究员，电话：021-64183618

潘洪玉，博士，助理研究员，电话：021-64432002
刘  蕾，硕士，助理研究员，电话：021-64432002

林河春，硕士，助理研究员，电话：021-64432002

耿  沁，大学本科，主管技师，电话：021-64432002
孔韩卫，大学本科，技师，电话：021-64437031 
朱淼鑫，大学本科，技师，电话：021-64432002
赵方瑜，大学本科，技师，电话：021-64432002

孙  磊，大学本科，技师，电话：021-64432002

代表性论文

[1] Tao Yu,Yingjun Zhao,Zhixiang Hu,Jing Li,Dandan Chu,Jiwei Zhang,Zhe Li,Bing Chen,Xiao Zhang,Hongyu Pan,Shengli Li,Hechun Lin,Lei Liu,Mingxia Yan,Xianghuo He*,and Ming Yao*.MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Research.2017,77(21):5782-5794.

[2] YING LIU,LEI LIU,TAO YU,HE‑CHUN LIN,DANDAN CHU,WEI DENG,MING‑XIA YAN,JING LI* and MING YAO*.Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes.Mol Med Rep.2016,14:5093-5103.

[3] Aiqin Gu,Jianhong Lu,Weimin Wang,Chunlei Shi,Baohui Han*, Ming Yao*.Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer. The International Journal of Biochemistry & Cell.2016, 70(2016):118-125

[4] T Yu, J Li, M Yan, L Liu, H Lin, F Zhao, L Sun, Y Zhang, Y Cui, F Zhang, J Li, X He, M Yao*. MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway. Oncogene.2015,34, 413–423

[5] Tao Yu,Lei Liu,Jing Li,Mingxia Yan,Hechun Lin,Ying Liu,Dandan Chu,Hong Tu,Aiqin Gu*,Ming Yao*.miRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN.Oncotarget. 2015,6(30):30239-30250

[6] Jing Li,Tao Yu,Jun Cao,Lei Liu,Ying Liu,Han-Wei Kong,Miao-Xin Zhu,He-Chun Lin,Dan-dan Chu,Ming Yao*,Ming-Xia Yan*.MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung.Cellular Physiology and Biochemistry.2015, 37:1847-1856  

[7] Yong-Qi Cui, Qin Geng, Tao Yu, Fang-Lin Zhang, He-Chun Lin, Jing Li, Miao-Xin Zhu, Lei Liu, Ming Yao*, Ming-Xia Yan*.Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line. international journal of oncology. 2015，47(3): 927-940 

[8] Wei Deng,Mingxia Yan, Tao Yu, Haiyan Ge,Hechun Lin,Jing Li,Ying Liu,Qin Geng,Miaoxin Zhu,Lei Liu, Xianghuo He*,Ming Yao*. Quantitative Proteomic Analysis of the Metastasis-Inhibitory Mechanism of miR-193a-3p in Non-Small Cell Lung Cancer. Cellular Physiology and Biochemistry.2015,35:1677-1688

[9] Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong,Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He, Ming Yao*. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25 . Molecular Cancer.2014, 13(166):1-14

[10] Fanglin Zhang, Hechun Lin, Aiqin Gu, Jing Li, Lei Liu, Tao Yu, Yongqi Cui,Wei Deng, Mingxia Yan, Jinjun Li*, Yao Ming*.SWATHTM- and iTRAQ-based quantitative proteomic analyses reveal an overexpression and biological relevance of CD109 in advanced NSCLC. Journal of Proteomics. 2014,102C: 125-136

[11] Lin He-chun, Zhang Fang-lin, Geng Qin, Yu Tao, Cui Yong-qi, Liu  Xiao-hui, Li Jing, Yan Ming-xia, Liu Lei, He Xiang-huo, Li Jin-jun, Yao Ming*.Quantitative Proteomic Analysis Identifies CPNE3 as a Novel Metastasis-promoting Gene in NSCLC. Journal of Proteome Research. 2013, 12(7), 3423-3433

[12] Wang Xiao-Min, Li Jing, Yan Ming-Xia, Liu Lei, Jia De-Shui, Geng Qin, Lin He-Chun, He Xiang-Huo, Li Jin-Jun, Yao Ming*. Integrative Analyses Identify Osteopontin, LAMB3 and ITGB1 as Critical Pro-Metastatic Genes for Lung Cancer. PLos One. 2013,8(2), e55714

所获项目

获得专利等其他

1.发明专利名称：人黑色素瘤高转移模型、细胞亚系以及建立方法和转移的动态检测

  发明专利授权号：ZL200910223845.6，授权时间：2013.07.10

  发明人：姚明，王晓敏，闫明霞，孔韩卫，刘蕾，萨冰清，李静

2.发明专利名称：人肺癌高转移细胞系SPC-A-1sci的建立

  发明专利授权号：ZL200710048188.7，授权时间：2011.01.08

  发明人：姚明，闫明霞，刘蕾孔韩卫，荚德水，吴海燕