课题组长：

李宗海 研究员

研究领域：

肿瘤免疫治疗

实验室成员：

周敏 博士

孙蕊心 博士

刘正阳 博士

博士研究生：

孙艳莎

刘逸凡

代表性论文：

1)     Sun R, Luo H, Su J, Di S, Zhou M, Shi B, Sun Y, Du G, Zhang H, Jiang H, Li Z Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice..Mol Ther. 2021 Jan 6;29(1):60-74.

2)     Luo H, Su J, Sun R, Sun Y, Wang Y, Dong Y, Shi B, Jiang H, Li Z.Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned Lymphodepletion. Clin Cancer Res. 2020 Oct 15;26(20):5494-5505.

3)     Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, Lu Q, Gao H, Jiang H, Wang H, Yuan D, Ma H, Wang H, Li Z, Zhai B.Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials. Clin Cancer Res. 2020 Aug 1;26(15):3979-3989.

4)     Hua Jiang, Zhimin Shi, PengWang, Cong Wang, Linlin Yang, Guoxiu Du, Honghong Zhang, Bizhi Shi, Jie Jia, Qixiang Li, Huamao Wang, Zonghai Li#. Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer. J Natl Cancer Inst. 2019,111(4):409-418

5)      Xiuqi Wu, Hong Luo, Bizhi Shi,Shengmeng Di,Ruixin Sun,Jingwen Su,Ying Liu, Hua Li,Hua Jiang,and Zonghai Li#. Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma. Mol Ther. 2019 Aug 7;27(8):1483-1494.

6)     Hua Jiang, Huiping Gao, Juan Kong, Bo Song, Peng Wang, Bizhi Shi, Huamao Wang, Zonghai Li#. Selective Targeting of Glioblastoma with EGFRvIII/EGFR Bi-targeted Chimeric Antigen Receptor T Cell. Cancer Immunol Res. 2018 ; 6(11):1314-1326

7)      Min Yu, Hong Luo, Mingliang Fan,Xiuqi Wu, Bizhi Shi, Shengmeng Di, Ying Liu, Zeyan Pan, Hua Jiang,and Zonghai Li#. Development of GPC3-Specific Chimeric Antigen Receptor-Engineered Natural Killer Cells for the Treatment of Hepatocellular Carcinoma. Molecular Therapy. 2018, 26(2):366-378

8)     Xiuqi Wu, Bizhi Shi, Jiqin Zhang, Zhimin Shi, Shengmeng Di, Minliang Fan, Huiping Gao, Hai Wang, Jianren Gu, Hua Jiang, Zonghai Li#. A fusion receptor as a safety switch, detection and purification biomarker for adoptive transferred T cells. Molecular Therapy. 2017, 25(10):2270-2279

9)     Huiping Gao, Kesang Li, Hong Tu, Xiaorong Pan, Hua Jiang, Bizhi Shi, Juan Kong,Hongyang Wang, Shengli Yang, Jianren Gu, and Zonghai Li#. Development of T cells redirected to glypican-3 for the treatment of hepatocellular carcinoma. Clin Cancer Res. 2014,20(24):6418-28；

10)   Min Zhou, Hai Wang, Keke Zhou, Xiaoying Luo, Xiaorong Pan, Bizhi Shi, Hua Jiang, Jiqin Zhang, Kesang Li, Hua-Mao Wang, Huiping Gao, Shun Lu, Ming Yao, Ying Mao, Hong-Yang Wang Shengli Yang, Jianren Gu, Chuanyuan Li, and Zonghai Li. A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells. Cancer Res. 2013,73:7056-7067

11)   Zonghai Li, Ruijiao Zhao, Xianghua Wu,Ye Sun, Ming Yao, Jinjun Li, Yuhong Xu, and Jianren Gu. Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. FASEB J. 2005, 19:1978–1985