王博石，博士，副研究员。2007年毕业于南京大学生命科学学院，获理学学士学位；2012年毕业于北京协和医学院，细胞生物学专业，获理学博士学位。2012年进入上海市肿瘤研究所，癌基因及相关基因国家重点实验室工作。主要从事蛋白质降解及相关调控蛋白在肿瘤发生发展中的作用研究。近年，先后主持国家自然科学基金2项，包括青年项目与面上项目各1项；主持上海交通大学医工交叉研究基金1项；2017年入选上海市青年科技启明星计划和上海市卫生系统优秀青年人才培养计划。以第一作者在Nature Communications, Molecular Carcinogenesis, Clinical Science等杂志发表论文6篇。

蛋白质降解及相关调控蛋白在肿瘤发生发展中的作用

1.    Boshi Wang; Aihui Ma; Li Zhang; Weilin Jin; Yu Qian; Guiqin Xu; Bijun Qiu; Zhaojuan Yang; Yun Liu; Qiang Xia; Yongzhong Liu, POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation, Nature Communications, 2015, 6: 8704 (第一作者)

2.    Boshi Wang; Yang Yang; Hai-Zhen Lu; Li Shang; Yu Zhang; Jiajie Hao; Zhizhou Shi; Xiaomin Wang; Yizhen Liu; Qimin Zhan; Xuemei Jia; Mingrong Wang, Inhibition of atypical protein kinase Cι induces apoptosis through autophagic degradation of β-catenin in esophageal cancer cells, Molecular Carcinogenesis, 2014, 53(7): 514-525 (第一作者)

3.    Boshi Wang; Yizhen Liu; Yang Yang; Yu Zhang; Jia-Jie Hao; Hai Yang; Xiao-Min Wang; Ziqiang Zhang; Qimin Zhan; Mingrong Wang, Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP, Clinical Science, 2013, 124(3): 203-214 (第一作者)

4.    Boshi Wang; Yang Yang; Hai Yang; Yizhen Liu; Jiajie Hao; Yu Zhang; Zhizhou Shi; Xuemei Jia; Qimin Zhan; Mingrong Wang, PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line, Cell Stress and Chaperones, 2013, 18(3): 359-366 (第一作者)

5.    Yu Qian; Boshi Wang; Aihui Ma; Li Zhang; Guiqin Xu; Qi Ding; Boshi Wang; Tiantian Jing; Lin Wu; Yun Liu; Zhaojuan Yang; Yongzhong Liu, USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells, Scientific Reports, 2016, 6: 33039 (并列第一作者)

6.    Yizhen Liu; Boshi Wang; Yanyi Jiang; Jian Cao; Jiajie Hao; Yu Zhang; Xin Xu; Yan Cai; Mingrong Wang, MCMs expression in lung cancer: implication of prognostic significance, Journal of Cancer, 2017, 8(18): 3641-3647 (并列第一作者)

7.    Jiabin Sun; Boshi Wang; Yun Liu; Li Zhang; Aihui Ma; Zhaojuan Yang; Yuhua Ji; Yongzhong Liu, Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression, Cancer Letters, 2014, 355(1): 25-33

8.    Jingyi Li; Yun Liu; Boshi Wang; Yingqian Xu; Aihui Ma; Feng Zhang; Chao Ge; Zhaojuan Yang; Jinjun Li; Yongzhong Liu, Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice, Carcinogenesis, 2013, 34(9): 2099-2108

9.    Yizhen Liu; Yanyi Jiang; Boshi Wang; Jiajie Hao; Li Shang; Tongtong Zhang; Jian Cao; Xin Xu; Qimin Zhan; Mingrong Wang, A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens, Cancer Cytopathology, 2014, 122(11): 833-841

10.  Shuguang Liu; Boshi Wang; Yanyi Jiang; Tongtong Zhang; Zhizhou Shi; Yang Yang; Yiling Yang; Xiaochun Wang; Dechen Lin; Yu Zhang; Hai Yang; Yan Cai; Qimin Zhan; Mingrong Wang, Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway, Molecular Cancer Research, 2011, 9(4): 390-402

1.    国家自然科学基金面上项目，课题号：81672359，2017.01-2020.12

2.    国家自然科学基金青年项目，课题号：81301716，2014.01-2016.12

3.   上海市青年科技启明星计划，课题号：17QA1403700，2017.04-2020.03

4.   上海市卫生系统优秀青年人才培养计划，课题号：2017YQ040，2017.07-2020.06

5.   上海交通大学医工交叉研究基金，课题号：YG2017MS51，2018.01-2020.12