甘愉，博士，上海市肿瘤研究所癌基因及相关基因国家重点实验室研究员，上海交通大学医学院博士研究生导师。2007 年毕业于复旦大学上海医学院，获得免疫学医学博士学位。2008 年至 2011 年在美国匹兹堡大学医学院从事博士后研究工作。2011 年底回国进入上海市肿瘤研究所。近年来先后主持国家自然科学基金3项，教育部博士点基金项目1项，上海市教委科研创新重点项目1项；作为项目骨干参与国家科技重大专项，国家重点研发计划“精准医学研究”专项，国家自然科学基金等多项国家和省部级课题。参与发表SCI论文40余篇，以第一、共同第一或通讯作者在Cancer Research、Annals of Neurology、Antioxidants & Redox Signaling等杂志发表SCI论文20余篇，参编英文论著3部。

肿瘤的系统性调控

1.         Xu D, Yuan H, Meng Z, Yang C, Li Z, Li M, Zhang Z, Gan Y*, Tu H*. Cadherin 13 Inhibits Pancreatic Cancer Progression and Epithelial-mesenchymal Transition by Wnt/β-Catenin Signaling. J Cancer. 2020 11(8):2101-2112.

2.         Meng Z, Liu T, Song Y, Wang Q, Xu D, Jiang J, Li M, Qiao J, Luo X, Gu J, Tu H*, Gan Y*. Exposure to an enriched environment promotes the terminal maturation and proliferation of natural killer cells in mice. Brain Behav Immun. 2019 77:150-160.

3.         Jiang J, Fan Y, Zhang W, Shen Y, Liu T, Yao M, Gu J, Tu H*, Gan Y*. Adiponectin suppresses human pancreatic cancer growth through attenuating the β-catenin signaling pathway. Int J Biol Sci. 2019 15(2):253-264.

4.         Li M#, Gan Y#, Fan C, Yuan H, Zhang X, Shen Y, Wang Q, Meng Z, Xu D, Tu H. Hepatitis B virus and risk of non-Hodgkin lymphoma: An updated meta-analysis of 58 studies. J Viral Hepat. 2018 25(8):894-903.

5.        Song Y, Gan Y*, Wang Q, Meng Z, Li G, Shen Y, Wu Y, Li P, Yao M, Gu J, Tu H*. Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerves-Dependent Regulation of NKG2D and CCR5. Cancer Res. 2017 77(7):1611-22.

6.        Lin C, Wang S, Xie W, Zheng R, Gan Y*, Chang J*. Apatinib inhibits cellular invasion and migration by fusion kinase KIF5B-RET via suppressing RET/Src signaling pathway. Oncotarget. 2016 7(37):59236-44.

7.        Wu Y#, Gan Y#, Yuan H, Wang Q, Fan Y, Li G, Zhang J, Yao M, Gu J, Tu H. Enriched environment housing enhances the sensitivity of mouse pancreatic cancer to chemotherapeutic agents. Biochem Biophys Res Commun. 2016 473(2):593-9.

8.        Lin C, Wang S, Xie W, Chang J*, Gan Y*. The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. Cancer Biol Ther. 2015 16(7): 1019-28.

9.        Fan Y#, Gan Y#, Shen Y, Cai X, Song Y, Zhao F, Yao M, Gu J, Tu H. Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget. 2015 6(18): 16120-34.

10.     Li G#, Gan Y#, Fan Y, Wu Y, Lin H, Song Y, Cai X, Yu X, Pan W, Yao M, Gu J, Tu H. Enriched environment inhibits mouse pancreatic cancer growth and down-regulates the expression of mitochondria-related genes in cancer cells. Sci Rep. 2015 5:7856.

11.     Wu S, Liu J, Wang X, Li M, Gan Y*, Tang Y*. Association of obesity and overweight with overall survival in colorectal cancer patients: a meta-analysis of 29 studies. Cancer Causes Control. 2014 25(11):1489-502.

12.     Wu Y#, Gan Y#, Gao F, Zhao Z, Jin Y, Zhu Y, Sun Z, Wu H, Chen T, Wang J, Sun Y, Fan C, Xiang Y, Qian G, Groopman JD, Gu J, Tu H. Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma. PLoS One. 2014 9(5):e94864

13.     Wu S#, Gan Y#, Wang X, Liu J, Tang Y. PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis. J Cancer Res Clin Oncol. 2013 139(5):891-900.

14.     Li P#, Gan Y#, Sun BL, Zhang F, Lu B, Gao Y, Liang W, Thomson LA, Chen J and Hu X. Adoptive regulatory T cell therapy protects against cerebral ischemia. Ann Neurol. 2013 74(3):458-71.

15.     Gan Y, Xing J, Jing Z, Stetler RA, Zhang F, Luo Y, Ji X, Gao Y, Cao G. Mutant erythropoietin without erythopoietic activity is neuroprotective against ischemic brain injury. Stroke. 2012 43(11):3071-7.

16.     Gan Y, Ji X, Hu X, Luo Y, Zhang L, Li P, Liu X, Yan F, Vosler PS, Gao Y, Stetler RA, Chen J. Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal. 2012 17(5):719-32.

1、国家自然科学基金面上项目，82073406，能量限制联合良性心理应激增强NK细胞抗肿瘤活性并抑制其衰竭的机制研究，2021-01至2024-12，55万元，主持

2、国家自然科学基金面上项目，81571618，丰富生存环境增强NK细胞抗肿瘤免疫的作用及机制研究，2016-01至2019-12，54万元，主持

3、国家自然科学基金面上项目，81572312，胰腺癌中乙肝病毒整合及整合靶基因MLL4的插入诱变机制研究，2016-01至2019-12，78万元，参加

4、国家自然科学基金青年基金项目，81201823、良性心理应激抑制肿瘤作用及其免疫调控机制：基于丰富生存环境小鼠肿瘤模型的研究，2013-01至2015-12，23万元，主持

5、教育部，高等学校博士学科点专项科研基金，20120073120094，脂肪因子Leptin和Adiponectin对胰腺癌发生发展的影响及机制研究、2013-01至2015-12，4万元，主持

工作人员

高见 博士 助理研究员

研究生

蒙姿宏（已毕业）、刘婷婷（已毕业）、杨春梅（已毕业）、李进、赵丹、杨含草