PhD Supervisors
| 姓名 | 王红阳 | 性别 | 女 |
| 专家类别 | 工程院院士 | ||
| 学历 | 博士 | 职称 | 主任医师，教授 |
| 联系电话 | 021-81875361 | 电子邮箱 | hywangk@vip.sina.com |
| 通讯地址 | 上海市杨浦区长海路225号东方肝胆外科医院三号楼6楼 | ||
| 招生信息: | 肿瘤学 博士/硕士 |
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个人简介
王红阳教授，女，主任医师，博士生导师，肿瘤学、分子生物学专家，中国工程院院士，发展中国家科学院院士，国家杰出青年基金获得者。现任国家肝癌科学中心主任、国际合作生物信号转导研究中心主任。兼任中国抗癌协会副理事长，中国医师协会精准医学专业委员会主任委员，上海市医学会副会长。
长期从事肿瘤的基础与临床研究，对肿瘤的炎-癌转化、信号网络调控和肝癌诊断试剂研发等有重要建树。在国际有影响的主流期刊发表SCI论文200余篇；近五年申报发明专利28项，已获授权12项（国际专利2项），主持研发的Glypican-3肝癌诊断试剂已获国家食品药品监督管理总局（CFDA）批复临床应用（是我国第一个具有完全自主产权获批的肝癌诊断试剂盒）。先后主持国家和省部级重大、重点科技攻关项目十余项。 以第一完成人获首届国家科学技术进步奖创新团队奖、国家自然科学二等奖、上海市自然科学一等奖、上海医学科技一等奖等9项，获全国三八红旗手标兵、总后勤部“科技金星”、上海市“十大科技精英”和上海市“优秀学科带头人”等称号，获韩国爱茉莉太平洋杰出女科学家奖，巾帼创新奖和首届“五洲女医师奖” 等。曾先后荣立一等功、二等功和三等功。
研究方向
肿瘤的基础与临床研究，肿瘤的信号网络调控、肝癌诊断标志物与药靶的筛选应用等
科研论文
1. Ou-Yang Q, Lin XM, Zhu YJ, Zheng B, Li L, Yang YC, Hou GJ, Chen X, Luo GJ, Huo F, Leng QB, Gonzalez FJ, Jiang XQ*, Wang HY*, Chen L*. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesis in Liver Regeneration and Hepatocarcinogenesis. Hepatology. 2018 Mar; 67(3):1071-1087（IF=11.711）
2. Fu J, Wang H*. Precision Diagnosis and Treatment of liver cancer in China. Cancer Lett 2018 Jan 1;412:283-288 （IF=6.38）
3. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y*, Wang H*. Contradictory Effects of Mitochondria- and Non-mitochondria-targeted Antioxidants on Hepatocarcinogenesis by Altering DNA Repair. Hepatology 2017 Sep 12. doi: 10.1002/hep.29518（IF=11.711）
4. Xiang DM, Sun W, Ning BF, Zhou TF, Li XF, Zhong W, Cheng Z, Xia MY, Wang X, Deng X, Wang W, Li HY, Cui XL, Li SC, Wu B, Xie WF, Wang HY*, Ding J*. The HLF/IL-6/STAT3 Feedforward Circuit Drives Hepatic Stellate Cell Activation to Promote Liver Fibrosis. GUT 2017 Jul 28.（IF=16.60）
5. Li XF, Chen C, Xiang DM, Qu L, Sun W, Lu XY, Zhou TF, Chen SZ, Cheng Z, Xia MY, Shen WF, Yang W, Wen W, Lee TKW, Cong WM, Wang HY*, Ding J*. Chronic Inflammation-elicited Liver Progenitor Cell Conversion to Liver Cancer Stem Cell with Clinical Significance. Hepatology 2017;66(6): 1934-1951 （IF=11.711）
6. Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*.Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology 2017 Apr 1, 152:1187-1202 （IF=18.187）
7. Wang C, Lv H, Yang W, Li T, Fang T, Lv G, Han Q, Dong L, Jiang T, Jiang B, Yang G*, Wang H*. SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts. Cancer Lett. 2017 Jul 10; 398:1-11 （IF=6.375）
8. Yang Y, Chen L, Gu J, Zhang H, Yuan J, Lian Q, Lv G, Wang S, Wu Y, Yang YT, Wang D, Liu Y, Tang J, Luo G, Li Y, Hu L, Sun X, Wang D, Guo M, Xi Q, Xi J, Wang H, Zhang MQ, Lu ZJ. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 2017 Feb 13;8:14421. doi: 10.1038/ncomms14421（IF=11.47）
9. Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY*, Yan HX*. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res. 2017 May;27(5):709-712（IF=15.606）
10. Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W*,Wang H*. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017 Jan;65(1):134-151（IF=11.055）
11. Chen S, Dong Z, Yang P, Wang X, Jin G, Yu H, Chen L, Li L, Tang L, Bai S, Yan H, Shen F, Cong W, Wen W*, Wang H*.Hepatitis B virus X protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis. Cancer Lett. 2017 May 28;394:22-32（IF=5.621）
12. Yue X, Ai J, Xu Y, Chen Y, Huang M, Yang X, Hu B, Zhang H, He C, Yang X, Tang W, Peng X, Dong L, Wang H*, Fan J, Ding J. Geng M.Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma. Hepatology. 2017 Jan 10. doi: 10.1002/hep.29036. [Epub ahead of print] （IF=11.055）
13. Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X, Yang W, Chen C, Xia M, Liu N, Yin S, Jin G, Lee T, Dong L, Hu H, Wang H*, Ding J*.Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients. Hepatology. 2017; 65(5):1566（IF=11.055）
14. Hou G, Chen L, Liu G, Li L, Yang Y, Yan HX, Zhang HL, Tang J, Yang YC, Lin X, Chen X, Luo GJ, Zhu Y, Tang S, Zhang J, Liu H, Gu Q, Zhao LH, Li Y, Liu L*, Zhou W*, Wang H*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling. Hepatology. 2017 .65(5):1628-（IF=11.055）
15. Guo X, Zhao Y, Yan H, Yang Y, Shen S, Dai X, Ji X, Ji F, Gong XG, Li L, Bai X, Feng XH, Liang T, Ji J, Chen L, Wang H, Zhao B. Single tumor-initiating cells evade immune clearance by recruiting type II macrophages. Genes Dev. 2017 Feb 1;31(3):247-259（IF=10.042）
16. Fang T, Lv H, Wu F, Wang C, Li T, Lv G, Tang L, Guo L, Tang S, Cao D, Wu M, Yang W*, Wang H*. Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation. Cancer Lett. 2017 . 1;384:50-59（IF=5.621）
17. Yun-Han Ma, Wei-Tao Dou, Yu-Fei Pan, Li-Wei Dong, Ye-Xiong Tan, Xiao-Peng He,* He Tian, and Hong-Yang Wang* . Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues. Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21（IF=18.96）
18. Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y, Chen W, Liu F, Sun W, Li XF, Wang X, Wang Y, Xu ZY, Gao L, Yang Q, Xu B, Li YM, Fang ZY, Xu ZP, Bao Y, Wu DS, Miao X, Sun HY, Sun YH, Wang HY*, Wang LH*. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-68 (IF= 23.214)
19. Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y, Wang H. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016 Aug 2;12(8):1355-71 （IF=8.593）
20. Ling-Hao Zhao*, Xiao Liu*, He-Xin Yan*, Wei-Yang Li*, Xi Zeng*, Yuan Yang*, Jie Zhao,Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu,Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang,Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan,Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu,Jun Wang, Huan-Ming Yang, Wei-Ping Zhou & Hong-Yang Wang* . Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun. 2016 Oct 5;7:12992（IF=11.47）
21. Wu FQ, Fang T, Yu LX, Lv GS, Lv HW, Liang D, Li T, Wang CZ, Tan YX, Ding J, Chen Y, Tang L, Guo LN, Tang SH, Yang W, Wang HY*, ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α. J Hepatol. 2016 Aug;65(2):314-24(IF= 10.59)
22. Yang C, Tan YX, Yang GZ, Zhang J, Pan YF, Liu C, Fu J, Chen Y, Ding ZW, Dong LW, Wang HY*.Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.J Exp Med. 2016 May 2;213(5):859-75 (IF= 11.24)
23. Wang X, Sun W, Shen W, Xia M, Chen C, Xiang D, Ning B, Cui X, Li H, Li X, Ding J, Wang H*. Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. J Hepatol. 2016 Jun;64(6):1283-94 (IF= 10.59)
24. Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW1, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY*.Acetyl-CoA carboxylase a promotion of glucose-mediated fatty acid synthesis enhances survival of HCC in mice and patients. Hepatology. 2016 Apr;63(4):1272-86 (IF=11.711)
25. Ann M.Bode, Zigang Dong*, Hongyang Wang*. Cancer prevention and control:alarming challenges in China. National Science Review 2016;3:117-127(IF=8.0)
26. Wang H*. Cancer Letters special issue hepatobiliary cancer featuring the guest editor. Cancer Lett. 2016 Sep 1;379(2):163(IF=5.992)
27. Cui X, Li X, Li J, Wang X, Sun W, Cheng Z, Ding J*, Wang H*. inFRank: a ranking-based identification of influential genes in biological networks. Oncotarget. 2017 Jul 4;8(27):43810-43821 (IF=5.008)
28. Li L, Chen J, Chen X, Tang J, Guo H, Wang X, Qian J, Luo G, He F, Lu X, Ding Y, Yang Y, Huang W, Hou G, Lin X, Ouyang Q, Li H, Wang R, Jiang F, Pu R, Lu J, Jin M, Tan Y, Gonzalez FJ, Cao G, Wu M, Wen H, Wu T, Jin L, Chen L*, Wang H*. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. Cancer Lett. 2016 Apr 10;373(2):234-40 (IF= 5.992)
29. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L*, Wang H*. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016 Jul;65(7):1186-201(IF=14.921)
30. Tang J, Li L, Huang W, Sui C, Yang Y, Lin X, Hou G, Chen X, Fu J, Yuan S, Li S, Wen W, Tang S, Cao D, Wu M, Chen L*, Wang H*. MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. Cancer Lett. 2015 Aug 1;364(1):33-43(IF=5.621)
31. Luo ZL, Cheng SQ, Shi J, Zhang HL, Zhang CZ, Chen HY, Qiu BJ, Tang L, Hu CL, Wang HY*, Li Z*.A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Nat Commun. 2015 Oct 7;6:8457. doi: 10.1038/ncomms9457 (IF= 11.47)
32. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, Ding J*, Wang HY*. 6PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol. 2015 Sep;63(3):651-60(IF=11.336)
33. Jiang F, Chen L, Yang YC, Wang XM, Wang RY, Li L, Wen W, Chang YX, Chen CY, Tang J, Liu GM, Huang WT, Xu L*, Wang HY*. CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling. Cancer Res. 2015 Apr 1; 75(7):1470-81(IF=9.329)
34. Zhang J, Jiang TY, Jiang BG, Yang C, Tan YX, Yang N, Pan YF, Ding ZW, Yang GZ, Wu MC, Dong LW*, Wang HY*. RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma. Oncotarget. 2015 Feb 20;6(5):3432-42 (IF=6.359)
35. Ding J*, Wen W, Xiang D, Yin P, Liu Y, Liu C, He G, Cheng Z, Yin J, Sheng C, Zhang W, Nan F, Ye W, Zhang X, Wang H*. ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. Oncotarget 2015 May 10;6(13):11627-39 (IF=6.359)
36. Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y*, Wang H*. Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology 2015 Feb;61(2):585-97(IF=11.055)
37. J Zhang, Y-F Pan, Z-W Ding, G-Z Yang, Y-X Tan, C Yang, T-Y Jiang, L-J Liu, B Zhang, T Han, D Cao, T Yang, N Yang, M-C Wu, L-W Dong* and H-Y Wang*. RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription. Oncogene 2015 Mar 19;34(12):1575-83 (IF=8.459)
38. Liang Li, Jing Tang, Baohua Zhang, Wen Yang, Miyang LiuGao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Jin Gu, Dingming Wu, Linna Guo, Dan Cao, Hengyu Li, Guangwen Cao, Mengchao Wu, Michael.Q Zhang, Lei Chen* and Hongyang Wang*. Epigenetic Modification of MiR-429 Promotes Liver Tumor-Initiating Cells Properties by Targeting Rb Binding Protein 4. GUT 2015 Jan;64(1):156-67 (IF=14.66)
39. Gu Q, Zhang B, Sun H, Xu Q, Tan Y, Wang G, Luo Q, Xu W, Yang S, Li J, Fu J, Chen L, Yuan S, Liang G, Ji Q, Chen SH, Chan CC, Zhou W, Xu X, Wang H*, Fang DD*. Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development. Oncotarget. 2015 Aug 21;6(24):20160-76(IF=6.359)
40. Wang FS*, Fan JG, Zhang Z, Gao B, Wang HY*. The Global Burden of Liver Disease: The Major Impact of China. Hepatology. 2014 Dec;60(6):2099-108 (IF=11.19)
41. Le-Xing Yu, Lei Yan, Wen Yang, Fu-Quan Wu, Yan Ling, Shu-Zhen Chen, Liang Tang,Ye-Xiong Tan, Dan Cao, Meng-Chao Wu, He-Xin Yan *& Hong-Yang Wang*. Platelets promote tumour metastasis via Q1 interaction between TLR4 and tumour cell-released high-mobility group box1 protein. Nature Communications 2014 Oct 28;5:5256(IF=10.742)
42. Fan JL, Zhang J, Dong LW, Fu WJ, Du J, Shi HG, Jiang H, Ye F, Xi H, Zhang CY, Hou J*, Wang HY*. URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription. Cell Death Dis. 2014 Mar 13;5:e1126 (IF= 5.177)
43. RuoYu Wang, Lei Chen, HaiYang Chen, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou, and HongYang Wang*. MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology 2013 Dec;145(6):1436-1448 (IF=12.821)
44. Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, Feng G, Zou D, Wang H*. Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma. Clin Cancer Res. 2013 Oct 1;19(19):5372-5380 (IF=7.837)
45. Wen Wen, Tao Han, Cheng Chen, Lei Huang, Wen Sun, Xue Wang, Shu-Zhen Chen, Dai-Min Xiang, Liang Tang, Dan Cao, Gen-Sheng Feng, Meng-Chao Wu, Jin Ding, and Hong-Yang Wang*. Cyclin G1 Expands Liver Tumor-Initiating Cells by Sox2 Induction via Akt/mTOR Signaling. Mol Cancer Ther. 2013 Sep;12(9):1796-1804 (IF=5.599)
46. Dai RY, Zhao XF, Li JJ, Chen R, Luo ZL, Yu LX, Chen SK, Zhang CY, Duan CY, Liu YP, Feng CH, Xia XM, Li H, Fu J, Wang HY*.Implication of transcriptional repression in compound C-induced apoptosis in cancer cells.
47. Cell Death Dis. 2013 Oct 24;4:e883 (IF=6.044)
48. B Zhang,L-W Dong,Y-X Tan,J Zhang,Y-F Pan,C Yang,M-H Li,Z-W Ding,L-J Liu,T-Y Jiang,J-H Yang*,and H-Y Wang*. Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma. British Journal of Cancer 2013 Jul 9;109(1):14-23(IF=5.082)
49. Chang Y, Liu C, Yang J, Liu G, Feng F, Tang J, Hu L, Li L, Jiang F, Chen C, Wang R, Yang Y, Jiang X, Wu M, Chen L, Wang H*.miR-20a triggers metastasis of gallbladder carcinoma. J Hepatol. 2013 Sep; 59(3):518-527(IF=9.858)
50. Pan YF, Tan YX, Wang M, Zhang J, Zhang B, Yang C, Ding ZW, Dong LW*, Wang HY*.Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression. Hepatology 2013 Aug;58(2):680-691 (IF=12.003)
51. Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW*, Wang HY*.The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma. Clin. Cancer Res. 2013 Apr 15;19(8):2014-2024 (IF=7.837)
科研项目
国家重大新药创制专项（387.52万元）； 国家自然科学基金委创新群体项目(600万元)；科技部重点研发计划“抗病毒天然免疫、炎症与癌变机制”专项（231万元）；上海市科委项目（50万元）多项等课题
实验室成员
陈磊、丁劲、陈瑶、杨文、文文