2008年毕业于东华大学，获材料学博士学位，同年7月进入上海市肿瘤研究所癌基因及相关基因国家重点实验室工作。研究方向为肿瘤靶向药物（基因）载体设计以及抗肿瘤给药系统的构建。作为课题负责人承担有国家自然科学基金面上项目2项，青年项目1项；上海市自然科学基金项目和卫生局项目各1项。作为科研骨干参与国家自然科学基金项目3项、上海市科委纳米科技研究项目2项。曾获上海市科学技术三等奖。参与发表SCI论文50余篇，在ACS Nano、Biomaterials、Journal of Materials Chemistry等期刊以第一作者、通讯作者发表文章二十余篇。获得授权国家发明专利四项。

1. 克服顺铂耐药相关递送系统的构建

2. 新型药物/基因递送系统的设计及应用

3. 多模态分子影像探针用于疾病诊治研究

4. 微流控系统用于肿瘤早期诊断

(1) Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan*, Ying Sun*. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478.

(2) Yunkai Zhu#, Ying Sun#, Weiyong Liu, Wenbin Guan, Huanhuan Liu, Yourong Duan*, Yaqing Chen*. Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer. Nanomedicine. 2020.

(3) Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan*, Ying Sun*. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065.

(4) Yanhua Zhang#; Hui Huang#; Hao Fu; Meng Zhao; Zhihua Wu; Yang Dong; He Li; Yourong Duan; Ying Sun*; Dual-mode US/MRI nanoparticles delivering siRNA and Pt(IV) for ovarian cancer treatment, RSC Advances, 2019, 9: 33302.

(5) Jie Xu#, Ying Sun#, Zeting Yuan#, Yijie Bao, Rongxin Li, Cheng Liu, YanYan Qiu, Ke Xu, Xiaojing Shi, Hui Yu, Teng Chen*, Yourong Duan*, Peihao Yin*. Bufalin-Loaded CaP/DPPE-PEG-EGF Nanospheres: Preparation, Cellular Uptake, Distribution, and Anti-Tumor Effects. Journal of Biomedical Nanotechnology. 2019, 15: 329–339.

(6) Ying Sun#, Qi Wang#, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics. 2017, 7(18): 4424-4444.

(7) Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun*, Xinyuan Liu*, Yourong Duan*. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560.

(8) Ying Sun#, Yunkai Zhu#, Can Huang, Rongxin Li, Yaqing Chen, Youron Duan. Magnetite loaded Polypeptide-PLGA multifunctional microbubbles for dual-mode US/MR imaging. Contrast Media & Molecular Imaging. 2016. 11(2): 146-153.

(9) Yunkai Zhu#, Ying Sun#, Yaqing Chen, Weiyong Liu, Jun Jiang，Wenbin Guan, Zhongyang Zhang, Yourong Duan. In Vivo Molecular MRI Imaging of Prostate Cancerby Targeting PSMA with Polypeptide-Labeled Superparamagnetic Iron OxideNanoparticles. International Journal of Molecular Sciences. 2015, 16: 9573-9587.

(10) Zelai He#, Ying Sun#, Qi Wang, Ming Shen, Mingjie Zhu, Fengqian Li, Yourong Duan. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL Copolymer-Prepared Nanoparticles. Journal of Physical Chemistry C. 2015, 119: 3348-3362.

1. 国家自然科学基金面上项目，81771839，电荷反转型共载Pt(IV)/siRNA纳米超声-磁共振双模态造影剂用于可视化治疗卵巢癌耐药的研究

2. 国家自然科学基金面上项目，81572999，微环境响应胞内质子介导释放ZD55-IL-24纳米靶向递送系统抑制肝癌转移作用及机制研究

3. 国家自然科学基金青年项目，81301973，多重靶向酶响应型载Au-Pt(IV)纳米载体的构建及对卵巢癌的治疗研究

1. 磷酸钙和两亲性聚合物复合载药纳米微球、制备方法和用途. 中国，ZL200910198765.X

2. 聚乙二醇-聚乳酸羟基乙酸-聚赖氨酸纳米递送系统、制备方法及其应用. 中国，ZL 200910247576.7

3. 核壳结构聚合物/纳米金复合纳米材料及其制备方法和应用. 中国，ZL201210246282.4

4. 肿瘤细胞及肿瘤血管双靶向纳米粒、构建方法及应用. 中国，ZL 201510503842.3

工作人员

武志华 博士 助理研究员

研究生

赵梦   硕士研究生

杨旭鹏 硕士研究生

胡粟衔 硕士研究生