罗晓莹，博士，副研究员。2009年毕业于中国科学院上海生命科学研究院生物化学与分子生物学专业，获理学博士学位。2002年毕业于西安交通大学生命学院，获理学硕士学位。1997年毕业于哈尔滨工程大学，获工学硕士学位。作为项目负责人承担国家自然科学基金面上项目、上海市科委自然科学基金项目、上海市卫生和计划生育委员会科研项目、国家重点实验室自主项目。以第一/通讯作者在Nano-micro Letters、Cancer Research、Neoplasia、Molecular Cancer和Cell Death Disease等杂志发表论文多篇。

肿瘤表观遗传学

囊泡为基础的肿瘤诊疗研究

1、Yong Yang *, Yusi Peng , Chenglong Lin, Li Long, Jingying Hu, Zhengren Huang*, Zhi-Yuan Li, Masaki Tanemura, Jianlin Shi, John R. Lombardi*, Xiaoying Luo*: Human ACE2-functionalized gold “virus-trap” nanostructures for accurate capture of SARS-CoV-2 and single-virus SERS detection. Nano-micro Letters (10.1007/s40820-021-00620-8).

1.    Zheng B, Wang J, Cai W, Lao I, Shi Y, Luo X*, Yan W*: Changes in the tumor immune microenvironment in resected recurrent soft tissue sarcomas. Annals of translational medicine 2019, 7(16):387.

2.    Tang C, Sun R, Wen G, Zhong C, Yang J, Zhu J, Cong Z, Luo X*, Ma C*: Bromocriptine and cabergoline induce cell death in prolactinoma cells via the ERK/EGR1 and AKT/mTOR pathway respectively. Cell death & disease 2019, 10(5):335.

3.    Yang Y, Jin Z, Dong R, Zheng C, Huang Y, Zheng Y, Shen Z, Chen G, Luo X*, Zheng S*: MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-gamma gene. Cell death & disease 2018, 9(5):545.

4.    Xu B, Nie Y, Liu X, Feng S, Yang Z, Wang Z, Zheng Q*, Luo X*: Quantitative analysis of APC promoter methylation in hepatocellular carcinoma and its prognostic implications. Oncology letters 2014, 7(5):1683-1688.

5.    Ma K, Pan X, Fan P, He Y, Gu J, Wang W, Zhang T, Li Z*, Luo X*: Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells. Molecular cancer 2014, 13:118.

6.    He Y, Cui Y, Xu B, Gu J, Wang W, Luo X*: Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma. PloS one 2014, 9(1):e87994.

7.    Zhou M#, Wang H#, Zhou K#, Luo X#, Pan X#, Shi B, Jiang H, Zhang J, Li K, Wang HM et al: A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells. Cancer research 2013, 73(23):7056-7067.

8.    Xu B, Di J, Wang Z, Han X, Li Z, Luo X*, Zheng Q*: Quantitative analysis of RASSF1A promoter methylation in hepatocellular carcinoma and its prognostic implications. Biochemical and biophysical research communications 2013, 438(2):324-328.

9.    Luo X#, Xie H, Long X, Zhou M, Xu Z, Shi B, Jiang H, Li Z: EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression. PloS one 2013, 8(12):e83332.

10.  He Y, Cui Y, Wang W, Gu J, Guo S, Ma K, Luo X*: Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia 2011, 13(9):841-853.

11.  Luo X, Zhang X, Shao W, Yin Y, Zhou J: Crucial roles of MZF-1 in the transcriptional regulation of apomorphine-induced modulation of FGF-2 expression in astrocytic cultures. Journal of neurochemistry 2009, 108(4):952-961.

1、国自然面上项目，MTHFR表达下调导致的DNA低甲基化在肝细胞癌发生发展中的作用及机制

2、上海市科委项目 肝细胞癌中miR-191诱导上皮-间质转分化机制研究

3、上海市卫计委项目 miR-103 在肝癌5-Fu 化疗药物敏感性中的作用及机制

实验室成员

敖军平  硕士   助理研究员

杨娟    硕士   助理研究员

胡晶莹  本科   主管技师

张源洲 硕士 研究实习员