2010年7月毕业于上海交通大学医学院，获病理学博士学位。毕业后在上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因与相关基因国家重点实验室工作。承担国家自然科学基金、上海市自然科学基金和教育部博士点基金等多项课题。参与发表SCI论文20余篇，作为第一作者或通讯作者在Hepatology、Cancer Research、Oncogene、Cancer Letters、Carcinogenesis、 Int J Cancer等杂志发表多篇SCI论文。

肿瘤发生发展相关分子机制研究

1. Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma. Cancer Res, 2021;81(5):1361-1374.

2. Zhou Q, Huang T, Jiang Z, Ge C, Chen X, Zhang L, Zhao F, Zhu M, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway. Oncogene. 2020;39(10):2140-2155.

3. Cao Y, Wang J, Tian H*, Fu GH*. Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer.J Exp Clin Cancer Res. 2020;39(1):119. 

4. Wei L, Zhou Q, Tian H*, Su Y, Fu GH, Sun T*. Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways. Int J Biol Sci. 2020;16(4):644-654.

5. Jiang Z, Zhou Q, Ge C, Yang J, Li H, Chen T, Xie H, Cui Y, Shao M, Li J, Tian H*. Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma.Cancer Lett. 2019;447:1-11. 

6. Liu Z, Yang J, Ge C, Zhao F, Li H, Yao M, Li J*, Tian H*. Inhibitor of binding/differentiation 2 (Id2) is regulated by CCAAT/enhancer-binding protein-α (C/EBPα) and promotes the proliferation of hepatocellular carcinoma. Am J Cancer Res. 2018;8(11):2254-2266

7.Su Y, Tian H*, Wei L, Fu G, Sun T*.Integrin β3 inhibits hypoxia-induced apoptosis in cardiomyocytes. Acta Biochim Biophys Sin (Shanghai). 2018;50(7):658-665. 

8.  Hou H, Ge C, Sun H, Li H, Li J, Tian H*.Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway.Cancer Sci. 2018;109(4):1088-1100.

9. Tian H, Ge C, Zhao F, Zhu M, Zhang L, Huo Q, Li H, Chen T, Xie H, Cui Y, Yao M, Li J*.Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma.Carcinogenesis. 2017;38(2):207-217.

10. Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J*.Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma.Hepatology. 2014;59(4):1459-70. 

11. Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, Fu GH*. Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells. Int J Cancer. 2010;127(6):1462-74

1、国家自然科学基金面上项目： AKR1C3对肝癌细胞增殖和转移的调控及其分子机制研究，课题编号：81972581， 2020-01~2023-12

2、上海市自然科学基金面上项目：AKR1C3对肝癌细胞转移的调控及其分子机制研究, 课题编号：19ZR1452800， 2019-07~2022-06

3、上海市卫健委卫生行业临床研究专项：SNX5通过EGFR通路调控肝癌细胞增殖和转移的机制研究，课题编号：201940429，2020-01~2022-12

4、国家自然科学基金面上项目： 锌α2糖蛋白在肝细胞癌中的表达调控及其作用机制研究，课题编号：81472570， 2015-01~2018-12

5、上海市卫计委课题面上项目：ITGA1在肝癌中的表达及其调控机制的研究，课题编号：201540107，2016-01~2018-12

6、教育部博士点基金：核糖核苷酸还原酶在肝细胞肝癌中的差异表达及其调控机制的研究，课题编号：20110073120105， 2012-01~2014-12

7、上海市自然科学基金面上项目： RRM2B对肝细胞癌AZGP1基因的表达调控及其分子机制的研究，课题编号：12ZR1430000， 2012-07~2015-06

8、上海市卫生局科研课题面上项目： p53R2在肝癌中的表达及其调控机制的研究，课题编号：20114169， 2012-01~2014-12 

工作人员：田伟，博士，助理研究员

研究生：黄婷婷，李嘉浚，陈金思，苏玉婷