1.    消化道肿瘤的表观遗传学修饰和信号通路

2.    胃肠道肿瘤癌前疾病的发生机制。

3.    消化道肿瘤分子分型

1.Yan T, Shen C, Jiang P, Yu C, Guo F, Tian X, Zhu X, Lu S, Han B, Zhong M, Chen J, Liu Q, Chen Y, Zhang J, Hong J, Chen H, Fang JY. Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling. Signal Transduct Target Ther. 2021;6(1):70. (共同通讯作者，IF=13.5)

2.Zhu X, Tian X, Ji L, Zhang X, Cao Y, Shen C, Hu Y, Wong JWH, Fang JY, Hong J, Chen H.A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients. NPJ Precis Oncol. 2021;5(1):7. doi: 10.1038/s41698-021-00142-x(通讯作者，IF=7.7)

3.Hong J, Guo F, Lu SY, Shen C, Ma D, Zhang X, Xie Y, Yan T, Yu T, Sun T, Qian Y, Zhong M, Chen J, Peng Y, Wang C, Zhou X, Liu J, Liu Q, Ma X, Chen YX, Chen H, Fang JY. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2020 Dec 14:gutjnl-2020-322780. doi: 10.1136/gutjnl-2020-322780. (共同通讯作者，IF=19.8)

4.Chen H, Zou TH, Xuan B, Yan Y, Yan T, Shen C, Zhao G, Chen YX, Xiao X, Hong J, Fang JY.

Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production. Signal Transduct Target Ther. 2020 Jul 8;5(1):121. doi: 10.1038/s41392-020-00237-0.(第一作者，IF=13.5)

5. Shen C, Xuan B, Yan T, Ma Y, Xu P, Tian X, Zhang X, Cao Y, Ma D, Zhu X, Zhang Y, Fang JY, Chen H, Hong J.m6A-dependent glycolysis enhances colorectal cancer progression. Mol Cancer. 2020 Apr 3;19(1):72. doi: 10.1186/s12943-020-01190-w. (共同通讯作者，IF=15.3)

6. Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, Zhong M, Chen J, Ge Z, Li X, Chen X, Cui Y, Chen Y, Zou W, Chen H, Hong J, Fang JY. LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 2019 Aug 2;10(1):3499. doi: 10.1038/s41467-019-11447-8. (共同通讯作者，IF=12.1)

7.      Yan TT, Ren LL, Shen CQ, Wang ZH, Yu YN, Liang Q, et al. miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer. Cancer Res. 2018;78(7):1751-65. (共同通讯作者，IF=9.13)

8.      Liang Q, Ma D, Zhu X, Wang Z, Sun TT, Shen C, et al. RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer. Clin Cancer Res. 2018;24(6):1473-85. (共同通讯作者，IF=10.2)

9.      Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell. 2017;170(3):548-63 e16. (共同通讯作者，IF=30.4.)

10.    Zhu X, Tian X, Yu C, Shen C, Yan T, Hong J, et al. A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Molecular cancer. 2016;15(1):60. (通讯作者，IF=15.2)

11.    Sun TT, He J, Liang Q, Ren LL, Yan TT, Yu TC, et al. LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer discovery. 2016;6(7):784-801. (共同通讯作者，IF=20.4)

（1）国家自然科学基金面上项目，2020/01-2023/12,

（2）国家自然科学基金面上项目，2018/01-2021/12,

（3）国家自然科学基金面上项目，2013/01-2016/12,

（4）上海市青年东方学者(特聘教授)和跟踪计划, 2014年/2017年

（5）上海市教委“高峰高原计划”, 2015年/2016年

（6）上海市自然科学基金面上项目,2013/07-2016/06

姓名: 洪洁; 研究员

姓名：宣宝琴；助理研究员

姓名：童天颖；学位：博士生；导师：陈豪燕

姓名：马燕如；学位：硕士生；导师：陈豪燕

姓名：胡慕妮；学位：硕士生；导师：陈豪燕