现任上海市肿瘤研究所癌基因及相关基因国家重点实验室实验病理学研究组组长。国家自然科学基金，国家科学技术奖及上海市科委等多个基金的评审专家，上海市实验动物学会副理事长，上海市医学会肿瘤靶分子专业委员会委员，《实验动物与比较医学》杂志副主编，《肿瘤》杂志编委等职务。主持国家自然科学基金面上项目、上海市科委创新行动计划等项目，参与国家科技重大专项、科技部“973"等各类课题多项。主持或主要参与的多个项目获得上海市医学科技二等奖、教育部自然科学奖二等奖、上海市科学技术进步一等奖等8项成果。发表SCI论文60余篇，其中通讯作者发表论文12篇，作为共同主编出版《人类疾病动物模型复制方法学》《实验动物学教程》2本，第一申请人申请发明专利6项，其中授权2项。

1、肿瘤动物模型的建立、高转移动物模型及细胞系的筛选

2、肺癌发生发展和侵袭转移的分子机制

3、高端科研平台的建立及应用研究

1.  Tao Yu,Yingjun Zhao,Zhixiang Hu,Jing Li,Dandan Chu,Jiwei Zhang,Zhe Li,Bing Chen,Xiao Zhang,Hongyu Pan,Shengli Li,Hechun Lin,Lei Liu,Mingxia Yan,Xianghuo He*,and Ming Yao*.MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Research.2017,77(21):5782-5794.

2.  YING LIU,LEI LIU,TAO YU,HE‑CHUN LIN,DANDAN CHU,WEI DENG,MING‑XIA YAN,JING LI* and MING YAO*.Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes.Mol Med Rep.2016,14:5093-5103.

3.   Aiqin Gu,Jianhong Lu,Weimin Wang,Chunlei Shi,Baohui Han*, Ming Yao*.Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer. The International Journal of Biochemistry & Cell.2016, 70(2016):118-125

4.   T Yu, J Li, M Yan, L Liu, H Lin, F Zhao, L Sun, Y Zhang, Y Cui, F Zhang, J Li, X He, M Yao*. MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway. Oncogene.2015,34, 413–423

5.   Tao Yu,Lei Liu,Jing Li,Mingxia Yan,Hechun Lin,Ying Liu,Dandan Chu,Hong Tu,Aiqin Gu*,Ming Yao*.miRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN.Oncotarget. 2015,6(30):30239-30250

6.   Jing Li,Tao Yu,Jun Cao,Lei Liu,Ying Liu,Han-Wei Kong,Miao-Xin Zhu,He-Chun Lin,Dan-dan Chu,Ming Yao*,Ming-Xia Yan*.MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung.Cellular Physiology and Biochemistry.2015, 37:1847-1856  

7.   o-Xin Zhu, Lei Liu, Ming Yao*, Ming-Xia Yan*.Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line. international journal of oncology. 2015，47(3): 927-940 

8.   Wei Deng,Mingxia Yan, Tao Yu, Haiyan Ge,Hechun Lin,Jing Li,Ying Liu,Qin Geng,Miaoxin Zhu,Lei Liu, Xianghuo He*,Ming Yao*. Quantitative Proteomic Analysis of the Metastasis-Inhibitory Mechanism of miR-193a-3p in Non-Small Cell Lung Cancer. Cellular Physiology and Biochemistry.2015,35:1677-1688

9.  Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong,Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He, Ming Yao*. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25 . Molecular Cancer.2014, 13(166):1-14

10.   Fanglin Zhang, Hechun Lin, Aiqin Gu, Jing Li, Lei Liu, Tao Yu, Yongqi Cui,Wei Deng, Mingxia Yan, Jinjun Li*, Yao Ming*.SWATHTM- and iTRAQ-based quantitative proteomic analyses reveal an overexpression and biological relevance of CD109 in advanced NSCLC. Journal of Proteomics. 2014,102C: 125-136

11.   Lin He-chun, Zhang Fang-lin, Geng Qin, Yu Tao, Cui Yong-qi, Liu  Xiao-hui, Li Jing, Yan Ming-xia, Liu Lei, He Xiang-huo, Li Jin-jun, Yao Ming*.Quantitative Proteomic Analysis Identifies CPNE3 as a Novel Metastasis-promoting Gene in NSCLC. Journal of Proteome Research. 2013, 12(7), 3423-3433

12.   Wang Xiao-Min, Li Jing, Yan Ming-Xia, Liu Lei, Jia De-Shui, Geng Qin, Lin He-Chun, He Xiang-Huo, Li Jin-Jun, Yao Ming*. Integrative Analyses Identify Osteopontin, LAMB3 and ITGB1 as Critical Pro-Metastatic Genes for Lung Cancer. PLos One. 2013,8(2), e55714 

1、发明专利名称：人黑色素瘤高转移模型、细胞亚系以及建立方法和转移的动态检测

  发明专利授权号：ZL200910223845.6，授权时间：2013.07.10

  发明人：姚明，王晓敏，闫明霞，孔韩卫，刘蕾，萨冰清，李静

2、发明专利名称：人肺癌高转移细胞系SPC-A-1sci的建立

  发明专利授权号：ZL200710048188.7，授权时间：2011.01.08

  发明人：姚明，闫明霞，刘蕾孔韩卫，荚德水，吴海燕

实验室成员：

       闫明霞，博士，副研究员

       潘洪玉，博士，助理研究员
       刘  蕾，硕士，助理研究员

       林河春，硕士，助理研究员

       耿  沁，大学本科，主管技师
       孔韩卫，大学本科，技师 
       朱淼鑫，大学本科，技师
       赵方瑜，大学本科，技师

       孙  磊，大学本科，技师